University of the Free State | UFS | Universities | Next Generation Sequencing Unit

PLOS ONE publication on proteome diversity in SARS-CoV-2 patients

Heatmap showing the protein abundance in urine, bronchoalveolar lavage fluid, gargle solution, and nasopharynx samples we analyzed.
The log2 centered intensity shows the level of protein abundance with “red” representing more abundant proteins and “blue” represents less abundant proteins. The patient groups are shown in the key to the right.

The team at the UFS-NGS Unit report a study that looked into the proteome profile in different human body sites of patients infected with the SARS-CoV-2 virus. The findings of the study, which were published in the Public Library of Science (PLOS ONE), indicated that urine and BALF had significantly more abundant SARS-CoV-2 proteins than the gargle solution and nasopharyngeal sites. The data demonstrated that a given body site is characterized by a unique set of proteins in SARS-CoV-2 seropositive individuals. This information contributes to knowledge in understanding SARS-CoV-2 pathogenesis.
The publication can be read here: